RS-422, also known as TIA/EIA-422, is a technical standard originated by the Electronic Industries Alliance that specifies electrical characteristics of a digital signaling circuit. It was meant to be the foundation of a suite of standards that would replace the older RS-232C standard with standards that offered much higher speed, better immunity from noise, and longer cable lengths. RS-422 systems can transmit data at rates as high as 10 Mbit/s, or may be sent on cables as long as 1,200 meters (3,900 ft) at lower rates. It is closely related to RS-423, which uses the same signaling systems but on a different wiring arrangement.

RS-422 specifies differential signaling, with every data line paired with a dedicated return line. It is the voltage difference between these two lines that define the mark and space, rather than, as in RS-232, the difference in voltage between a data line and a local ground. As the ground voltage can differ at either end of the cable, this required RS-232 to use signals with voltage magnitudes greater than 5 volts. Moving to dedicated return lines and always defining ground in reference to the sender allows RS-422 to use 0.4 V, allowing it to run at much higher speeds. RS-423 differs primarily in that it has a single return pin instead of one for each data pin.